魚(yú)類發(fā)育與生物技術(shù)
學(xué)科帶頭人：孫永華?研究員
學(xué)科組成員：
朱作言?研究員、院士、孫永華?研究員、葉鼎?副研究員、何牡丹 項(xiàng)目副研、王厚鵬 實(shí)驗(yàn)師?
聯(lián)系方式：
027-68780235（孫永華辦）；027-68780935（實(shí)驗(yàn)室）
學(xué)科組介紹：
????? 高效繁育和優(yōu)良品種是可持續(xù)發(fā)展水產(chǎn)養(yǎng)殖的前提，魚(yú)類發(fā)育與生物技術(shù)學(xué)科組致力于解決高效繁育的魚(yú)類生殖細(xì)胞發(fā)育研究和培育優(yōu)良品種的前沿育種生物技術(shù)研發(fā)。?
????? 學(xué)科組的主要研究興趣包括：?
??????1）?魚(yú)類生殖干細(xì)胞命運(yùn)決定和分化、配子發(fā)生、胚胎發(fā)育的分子和細(xì)胞學(xué)機(jī)制研究；?
???? ?2）?穩(wěn)定高效的基因編輯和借腹生殖等魚(yú)類前沿育種生物技術(shù)的研發(fā)；?
??????3）?優(yōu)質(zhì)、高產(chǎn)的養(yǎng)殖魚(yú)類新種質(zhì)的研制和快速定向育種。?
????? 學(xué)科組已建立一整套成熟的遺傳學(xué)、細(xì)胞生物學(xué)、生物化學(xué)、生物影像學(xué)、多組學(xué)分析等多元化的研究技術(shù)平臺(tái)，在魚(yú)類生殖細(xì)胞與胚胎發(fā)育的育種基礎(chǔ)理論研究、規(guī)?；z傳和育種模型構(gòu)建、基因編輯配子“借腹生殖”前沿育種生物技術(shù)研發(fā)等方面取得重要進(jìn)展。學(xué)科組在 Genome Research、PLOS Biology、Nature Communications、PLOS Genetics、Journal of Biological Chemistry、Endocrinology、Cell Research、Science Bulletin等國(guó)內(nèi)外學(xué)術(shù)刊物上發(fā)表論文100 余篇。?
????? 學(xué)科組目前承擔(dān)有“發(fā)育編程及其代謝調(diào)節(jié)”國(guó)家重點(diǎn)研發(fā)計(jì)劃重點(diǎn)專項(xiàng)、國(guó)家杰出青年科學(xué)基金、國(guó)家自然科學(xué)基金創(chuàng)新研究群體、國(guó)家自然科學(xué)基金面上項(xiàng)目、中科院先導(dǎo)專項(xiàng)等一批科研項(xiàng)目。?
近三年發(fā)表的主要論文（* 示通訊作者）：
??? 1)?Zhang, F., Hao, Y., Li, X., Li, Y., Ye, D., Zhang, R., Wang, X., He, M., Wang, H., Zhu, Z., and?Sun, Y.* (2022). Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation.?Sci China Life Sci?65, 969-987. 10.1007/s11427-021-1989-9.?
??? 2)?Wang, Y., Ye, D., Zhang, F., Zhang, R., Zhu, J., Wang, H., He, M., and?Sun, Y.*?(2022). Cyp11a2 Is Essential for Oocyte Development and Spermatogonial Stem Cell Differentiation in Zebrafish.?Endocrinology?163. 10.1210/endocr/bqab258.?
??? 3)?Ye, D., and?Sun, Y.*?(2021). Manipulating and Visualizing the Germline with Transgenic Lines.?Methods Mol Biol?2218, 265-276. 10.1007/978-1-0716-0970-5_21.?
??? 4)?Mohammed, Y., Ye, D., He, M., Wang, H., Li, Y., Han, D., Zhu, Z., and?Sun, Y.*?(2021). Induction of biosynthesis of ketocarotenoid from β-carotene in fish embryos.?Aquaculture?542, 736863. 10.1016/j.aquaculture.2021.736863.?
??? 5)?He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., and?Sun, Y.*?(2020). Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.?PLOS Biology?18, e3000561.? ?
??? 6)?Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., et al. (2020). Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9.?Genome Research?30, 118–126.?
??? 7)?Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y., and Zhang, Y.A. (2020). A critical role of foxp3a-positive regulatory T cells in maintaining immune homeostasis in zebrafish testis development. J Genet Genomics 47, 547-561. 10.1016/j.jgg.2020.07.006.（封面論文）?
??? 8)?Zhang, Q., Ye, D., Wang, H., Wang, Y., Hu, W., and?Sun, Y.*?(2020). Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.?Endocrinology?161, DOI:10.1210/endocr/bqaa048?（2020、2021年度高被引論文）?
??? 9)?Zhang, F., Li, X., He, M., Ye, D., Xiong, F., Amin, G., Zhu, Z., and?Sun, Y.*?(2020). Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells.?Journal of Genetics and Genomics?47, 37-47.?(Faculty of 1000推薦論文)???
??? 10)?Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., and?Sun, Y.*?(2019). Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b.?PLOS Genetics?15, e1008306.?
??? 11) Ye, D., Zhu, L., Zhang, Q., Xiong, F., Wang, H., Wang, X., He, M., Zhu, Z., and?Sun, Y.*?(2019). Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline.?Mar Biotechnol (NY)?21, 217-228.?(Springer Nature 2019 Highlights論文)?
??? 12)?Sun, Y.*, and Zhu, Z. (2019). Designing future farmed fishes using genome editing.?Sci China Life Sci?62, 420-422. 10.1007/s11427-018-9467-x.?
